Endocrine Abstracts

Background: In people with HIV on ARV treatment receiving Dolutegravir (DTG)-based regimen, weight and lipodystrophy have been reported.Aim: The aim of this is to evaluate the effect of DTG on the lipid profile and fat distribution on patients who have been switched from a non to a Dolutegravir (DTG)-based regimen on the lipid profile and fat distribution.Methods: One hundred patients above 18yrs of age were recruited into two arms...

Background: Adrenal insufficiency has been well established in patients with pulmonary tuberculosis in Nigeria. It has however not been well documented in patients with extra pulmonary TB. This study compared the adrenal function in patients with pulmonary TB vs those with extra pulmonary TB.Methods: We randomized 100 cases of pulmonary TB and 50 cases of diagnosed extra pulmonary TB, with the aim of assessing the adreno-cortical functions using both ser...

Background: Highly Active Antiretroviral Therapy (HAART) has improved the health and wellbeing of people living with HIV, but at the same time, it causes excessive weight gain through abnormal fat distribution (lipodystrophy). Overweight and obesity have implications on the cardiovascular status of these patients. We aimed to determine the change in BMI after the commencement of HAART and the factors associated with this change.Methodology: It was a long...

Objective: To determine the prevalence of overweight and obesity and it’s associated risk factors in a rural population in Kano, northwestern Nigeria.Materials and methods: Thousand and twenty four men and women aged 18 years and above, who reside in Kumbotso ward in Kano, northwestern Nigeria were enrolled into the study using a multistage random sampling technique over a 5 months period (November 2014–April 2015). Anthropometric indices, heig...

Background: The use of Dolutegravir (DTG) in the treatment of patients with HIV has been associated with reports of unexpected excess weight gain. The present study aimed to investigate the effect of DTG on the adrenal cortisol levels of HIV patients initiated on antiretroviral therapy (ART).Methods: Adult patients (≥18 years) newly initiated on ART were recruited into two groups (n-100 participants in each group). One group was initiated on a DTG-...

Background: The use of Dolutegravir (DTG) in the treatment of patients with HIV has been associated with reports of unexpected excess weight gain. The present study aimed to investigate the effect of DTG on the adrenal cortisol levels of HIV patients initiated on antiretroviral therapy (ART).Methods: Adult patients (≥18 years) newly initiated on ART were recruited into two groups (n-100 participants in each group). One group was initiated on a DTG-...

Background: The exposure to HAART has increased the chances of developing Diabetes among HIV patients. Hyperglycaemia is more common among those on Protease inhibitors (PI)-based regimens compared to other regimens. Glycated hemoglobin (HbA1c ) is now being recommended by the American Diabetes Association (ADA) for the screening of Diabetes because of convenience as it does not require fasting.Objective: We aimed to dete...

Background: The exposure to HAART has increased the chances of developing Diabetes among HIV patients. Hyperglycaemia is more common among those on Protease inhibitors (PI)-based regimens compared to other regimens. Glycated hemoglobin (HbA1c ) is now being recommended by the American Diabetes Association (ADA) for the screening of Diabetes because of convenience as it does not require fasting.Objective: We aimed to dete...

Background: The lipid profile of healthy adults in northern Nigeria is scarcely reported in literature. Yet, hospital records show increasing frequency of dyslipidemia-related illnesses like CVA, MI, and peripheral vascular diseases in practice. We aim to report the pattern of lipid abnormalities in a rural population in Kano, Nigeria.Methods: A population screening of apparently healthy adults resident in sub urban community in Kano was undertaken over ...

Background: Highly active antiretroviral therapy (HAART) particularly protease inhibitors cause hyperglycaemia through insulin resistance. There is raising number of HIV patients on HAART attending the diabetic clinic in Nigeria and very few studies were done to determine their risk of developing diabetes. We aimed to determine the prevalence and factors associated with diabetes mellitus (DM) among HIV patients.Methods: In a cross sectional study of 300 ...